Research

Our research group aims to clarify how sensory functions in the oral and maxillofacial regions are processed by the brain. We`d like to ultimately contribute to the development of new treatments for intractable and chronic diseases by controlling these mechanisms. We particularly emphasize advancing research within the broad framework of neuroscience, including morphology, physiology, and molecular biology, without being confined to the field of pharmacology. The specific content is as follows:

1. Mechanisms of Taste Information Processing in the Higher Brain

   Oral sensations are essential for the processes of tasting, chewing, and swallowing food. Among the sensations involved, taste is particularly influenced by past experiences. This means that information (memories) held by higher brain areas such as the cerebral cortex profoundly affects the processing of currently experienced taste information. We are taking a multi-level, longitudinal approach, utilizing non-invasive brain imaging techniques (fMRI, PET, MEG), patch-clamp methods, optical measurement, and molecular biology techniques to clarify the mechanisms by which taste information is processed, particularly in the insular cortex.

2. Mechanisms of Pain Information Processing in the Insular Cortex

   Pain control is one of the most crucial issues in dental clinical practice. We are particularly focusing on intractable chronic pain and ultimately aim to clarify the mechanisms of pain chronification due to neural plasticity. For this purpose, we have established multi-patch clamp methods and in vivo calcium imaging methods in chronic animal models and are engaged in research.

To advance the above research, we are actively collaborating on joint research projects with external research institutions such as the Department of Physiology at this university's graduate school, Nihon University College of Science and Technology, Fukushima Medical University, Doshisha University, Hyogo College of Medicine, Nagasaki University, University of Toronto, RIKEN, and others. We also actively provide opportunities for young researchers to gain experience at top universities in North America to further advance their careers.