研究業績
2024
総説
原著
Iida M, Hitomi S, Hayashi Y, Shibuta I, Tsuboi Y, Ueda K, Iwata K, Shinoda M. (2024) Analgesic effect of linalool odor on oral ulcerative mucositis-induced pain in rats. Brain Res Bull. 206:110844. Sunaga M, Tsuboi Y, Kaizu A, Shinoda M. (2024) Role of macrophages in trigeminal ganglia in ectopic orofacial pain associated with pulpitis. J Oral Biosci. S1349-0079(24)00014-8.
2023
総説
原著
Kurisu R, Saigusa T, Aono Y, Hayashi Y, Hitomi S, Shimada M, Iwata K, Shinoda M. (2023) Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury-induced mechanical allodynia. Oral Dis. 29(4):1770-1781. Fujiwara S, Urata K, Oto T, Hayashi Y, Hitomi S, Iwata K, Iinuma T, Shinoda M. (2023) Age-related Changes in Trigeminal Ganglion Macrophages Enhance Orofacial Ectopic Pain After Inferior Alveolar Nerve Injury. In Vivo. 37(1):132-142. Nakaya Y, Iwata K, Kobayashi M. (2023) Insular cortical descending projections facilitate neuronal responses to noxious but not innoxious stimulation in rat trigeminal spinal subnucleus caudalis. Brain Res. 1804:148248. Soma K, Hitomi S, Hayashi Y, Soma C, Otsuji J, Shibuta I, Furukawa A, Urata K, Kurisu R, Yonemoto M, Hojo Y, Shirakawa T, Iwata K, Shinoda M. (2023) Neonatal injury modulates incisional pain sensitivity in adulthood: An animal study. Neuroscience. 519:60-72. Hitomi S, Nodai T, Kokabu S, Shikayama T, Sago-Ito M, Nakatomi C, Terawaki K, Omiya Y, Shinoda M, Ono K. (2023) Hepcidin expression in the trigeminal ganglion and the oral mucosa in an oral ulcerative mucositis rat model. PLOS ONE. 18(4):e0284617. Hayashi Y, Otsuji J, Oshima E, Hitomi S, Urata K, Ikuko S, Iwata K, Shinoda M. (2023) Microglia cause structural remodeling of noradrenergic axon in the trigeminal spinal subnucleus caudalis after infraorbital nerve injury in rats. Brain, Behavior, & Immunity – Health. 30:100622. Kaizu A, Tsuboi Y. (2023) Creation of myofascial pain syndrome-like muscle by artificial electrical stimulation and stretching treatment. J Neurosci Methods. in press.
Akasaka R, Hayashi Y, Furukawa A, Hitomi S, Koyama R, Oshima E, Tamura M, Yonemoto M, Hojo Y, Takahashi R, Shibuta I, Iwata K, Yonehara Y, Shinoda M. (2023) PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve terminals contributes to tongue cancer pain. J Oral Biosci. S1349-0079(23)00131-7.
Oshima E, Hayashi Y, Zhen X, Sato H, Hitomi S, Shibuta I, Urata K, Ni J, Iwata K, Shirota T, Shinoda M. (2023) M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast– Schwann cell signaling relay. J Neuroinflammation. 20(1):258. Asano S, Okada-Ogawa A, Kobayashi M, Yonemoto M, Hojo Y, Shibuta I, Noma N, Iwata K, Shinoda M. (2023) Involvement of Interferon Gamma Signaling in Spinal Trigeminal Caudal Subnucleus Astrocyte in Orofacial Neuropathic Pain in Rats with Infraorbital Nerve Injury. Mol Pain. 10:17448069231222403. Soma C, Hitomi S, Oshima E, Hayashi Y, Soma K, Shibuta I, Tsuboi Y, Shirakawa T, Kikuiri T, Iwata K, Shinoda M. (2023) Involvement of oxidative stress in orofacial mechanical pain hypersensitivity following neonatal maternal separation in rats. Sci Rep. 13(1):22760.
2022
総説
Shinoda M, Hitomi S, Iwata K, Hayashi Y. (2022) Plastic changes in nociceptive pathways contributing to persistent orofacial pain. J Oral Biosci. 64(3): 263-270.
原著
Hong C, Hayashi Y, Hitomi S, Kurisu R, Urata K, Shibuta I, Toyofuku A, Iwata K, Shinoda M. (2022) Astrocytic and microglial interleukin-1β mediates complement C1q triggered orofacial mechanical allodynia. Neurosci Res. in press. Kimura Y, Hayashi Y, Hitomi S, Ikutame D, Urata K, Shibuta I, Sakai A, Ni J, Iwata K, Tonogi M, Shinoda M. (2022) IL-33 induces orofacial neuropathic pain through Fyn-dependent phosphorylation of GluN2B in the trigeminal spinal nucleus caudalis. Brain Behav Immun. 99:266-280. Oto T, Urata K, Hayashi Y, Hitomi S, Shibuta I, Iwata K, Iinuma T, Shinoda M. (2022) Age-Related Differences in Transient Receptor Potential Vanilloid 1 and 2 Expression Patterns in the Trigeminal Ganglion Neurons Contribute to Changes in the Palatal Mucosal Heat Pain Sensitivity. Tohoku J Exp Med. 256(4):283-290. Otsuji J, Hayashi Y, Hitomi S, Soma C, Soma K, Shibuta I, Iwata K, Shirakawa T, Shinoda M. (2022) Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats. Sci Rep. 12(1):19314. Xie Z, Meng J, Kong W, Wu Z, Lan F, Narengaowa, Hayashi Y, Yang Q, Bai Z, Nakanishi H, Qing H, Ni J. (2022) Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease. Aging Cell. 21(3):e13565. Xie Z, Meng J, Wu Z, Nakanishi H, Hayashi Y, Kong W, Lan F, Narengaowa, Yang Q, Qing H, Ni J. (2022) The Dual Nature of Microglia in Alzheimer's Disease: A Microglia-Neuron Crosstalk Perspective. Neuroscientist. 10738584211070273. Liu Y, Li H, Hu J, Wu Z, Meng J, Hayashi Y, Nakanishi H, Qing H, Ni J. (2022) Differential Expression and Distinct Roles of Proteinase-Activated Receptor 2 in Microglia and Neurons in Neonatal Mouse Brain After Hypoxia-Ischemic Injury. Mol Neurobiol. 59(1):717-730. Nakatomi C, Hitomi S, Yamaguchi K, Hsu CC, Harano N, Iwata K, Ono K. (2022) Effect of cisplatin on oral ulcer-induced nociception in rats. Arch Oral Biol. 144:105572. Nakatomi C, Hitomi S, Yamaguchi K, Hsu CC, Seta Y, Harano N, Iwata K, Ono K. (2022) Cisplatin induces TRPA1-mediated mechanical allodynia in the oral mucosa. Arch Oral Biol. 133:105317. Ohyama S, Ouchi T, Kimura M, Kurashima R, Yasumatsu K, Nishida D, Hitomi S, Ubaidus S, Kuroda H, Ito S, Takano M, Ono K, Mizoguchi T, Katakura A, Shibukawa Y. (2022) Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity. Front Physiol. 13:891759. Kubo A, Sugawara S, Iwata K, Yamaguchi S, Mizumura K. (2022) Masseter muscle contraction and cervical muscle sensitization by nerve growth factor cause mechanical hyperalgesia in masticatory muscle with activation of the trigemino-lateral parabrachial nucleus system in female rats. Headache. 62(10):1365-1375.
2021
総説
Shinoda M, Imamura Y, Hayashi Y, Noma N, Okada-Ogawa A, Hitomi S, Iwata K (2021) Orofacial neuropathic pain -basic research and their clinical relevancies. Front Mol Neurosci. 14:691396. Nakanishi H , Ni J, Nonaka S, Hayashi Y. (2021) Microglial circadian clock regulation of microglial structural complexity, dendritic spine density and inflammatory response. Neurochem Int. 142:104905.
原著
Murakami N, Yoshikawa K, Tsukada K, Kamio N, Hayashi Y, Hitomi S, Kimura Y, Shibuta I, Osada A, Sato S, Iwata K, Shinoda M. (2021) Butyric acid modulates periodontal nociception in Porphyromonas gingivalis-induced periodontitis. J Oral Sci. doi: 10.2334/josnusd.21-0483. Osada A, Hitomi S, Nakajima A, Hayashi Y, Shibuta I, Tsuboi Y, Motoyoshi M, Iwata K, Shinoda M. (2021) Periodontal acidification contributes to tooth pain hypersensitivity during orthodontic tooth movement. Neurosci Res. S0168-0102(21)00241-8. Miyamura Y, Hitomi S, Omiya Y, Ujihara I, Kokabu S, Morimoto Y, Ono K. (2021) Isoliquiritigenin, an active ingredient of Glycyrrhiza, elicits antinociceptive effects via inhibition of Na v channels. Naunyn Schmiedebergs Arch Pharmacol. 394(5):967-980. Koyama R, Iwata K, Hayashi Y , Hitomi S, Shibuta I, Furukawa A, Asano S, Kaneko T, Yonehara Y, Shinoda M. (2021) Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal Subnucleus Caudalis Is Involved in Tongue Cancer Pain. Int J Mol Sci. 22 (21):11404. Inada T, Sato H, Hayashi Y , Hitomi S, Furukawa A, Shibuta I, Tsuda H, Iwata K, Shirota T, Shinoda M. (2021) Rapamycin accelerates axon regeneration through Schwann cell-mediated autophagy following inferior alveolar nerve transection in rats. Neuroscience. 468:43-52. Tsuchimochi A, Endo C, Motoyoshi M, Tamura M, Hitomi S, Hayashi Y, Shinoda M. (2021) Effect of low-intensity pulsed ultrasound on orofacial sensory disturbance following inferior alveolar nerve injury: role of neurotrophin-3 signaling. Eur J Oral Sci. e12810. Matsui T, Hitomi S , Hayashi Y, Shibuta I, Otsuji J, Ando M, Inada T, Soma K, Iwata K, Shirakawa T, Shinoda M. (2021) Microglial activation in the trigeminal spinal subnucleus interpolaris/caudalis modulates orofacial incisional mechanical pain hypersensitivity associated with orofacial injury in infancy. J Oral Sci. 63(2):170-173. Koizumi M, Asano S, Furukawa A, Hayashi Y, Hitomi S, Shibuta I, Hayashi K, Kato F, Iwata K, Shinoda M. (2021) P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats. J Headache Pain. 22:31. Miyamura Y, Hitomi S, Omiya Y, Ujihara I, Kokabu S, Morimoto Y, Ono K. (2021) Isoliquiritigenin, an active ingredient of Glycyrrhiza, elicits antinociceptive effects via inhibition of Nav channels. Naunyn Schmiedebergs Arch Pharmacol. 394(5):967-980. Nakatomi C, Yoshino K, Shono Y, Miyamura Y, Hitomi S, Ujihara I, Ono K . (2021) The effect of flavor on the oral perception and palatability of viscosity in healthy human subjects. J Oral Biosci. 63(1):91-96. Okada S, Iwata K, Katagiri A . (2021) Pathognomonic hypersensitivity of the oral mucosa and tongue induced by diabetes mellitus accompanied by saliva reduction in rats. J Oral Facial Pain Headache. 35(1):54-61. 遠藤千登世, 土持茜, 本吉満, 篠田雅路 (2021) 低出力超音波パルスによる切断下歯槽神経の機能的再生に対する脳由来神経栄養因子の役割. 日大歯学. 95(2):119-124.
2020
著書
篠田雅路 他 分担 (2020) 臨床現場で役に立つ“痛み”の教科書 和嶋浩一/石井隆資/島田淳編 デンタルダイヤモンド社 東京 672, 164-169頁
総説
Shinoda M , Hayashi Y, Kubo A, Iwata K. (2020) Pathophysiological mechanisms of persistent orofacial pain. J Oral Sci. 62(2):131-135.Imamura Y , Okada-Ogawa A, Noma N, Shinozaki T, Watanabe K, Kohashi R, Shinoda M, Wada A, Abe O, Iwata K. (2020) A perspective from experimental studies of burning mouth syndrome. J Oral Sci. 62(2):165-169.
原著
Unno S, Shinoda M, Soma K, Kubo A, Sessle BJ, Matsui T, Ando M, Asaka J, Otsuki K, Yonemoto H, Onose H, Sakanashi K, Iwata K. (2020) Properties of heat-sensitive neurons in the premotor cortex in awake behaving monkeys. J Oral Sci. 62(4):382-386. Chen JY, Kubo A, Shinoda M, Okada-Ogawa A, Imamura Y, Iwata K. (2020) Involvement of TRPV4 ionotropic channel in tongue mechanical hypersensitivity in dry-tongue rats. J Oral Sci. 62(1):13-17. Soma K, Shinoda M, Hayashi Y, Kanno K, Shirakawa T, Iwata K. (2020) Involvement of TNFα in the enhancement of hypersensitivity in the adulthood-injured face associated with facial injury in infancy. Neurosci Res. S0168-0102(19)30657-1. Lee J , Ohara K, Shinoda M, Hayashi Y, Kubo A, Sugawara S, Asano S, Soma K, Kanno K, Ando M, Koyama R, Kimura Y, Sakanashi K, Iinuma T, Iwata K. (2020) Involvement of satellite cell activation via nitric oxide signaling in ectopic orofacial hypersensitivity. Int J Mol Sci. 21(4): E1252.Shinoda M , Fujita S, Sugawara S, Asano S, Koyama R, Fujiwara S, Soma K, Tamagawa T, Matsui T, Ikutame D, Ando M, Osada A, Kimura Y, Kobayashi K, Yamamoto T, Kusama-Eguchi K, Kobayashi M, Hayashi Y, Iwata K. (2020) Suppression of superficial microglial activation by spinal cord stimulation attenuates neuropathic pain following sciatic nerve injury in rats. Int J Mol Sci. 21(7):2390.Asano S, Hayashi Y , Iwata K, Okada-Ogawa A, Hitomi S, Shibuta I, Imamura Y, Shinoda M. (2020) Microglia-astrocyte communication via C1q contributes to orofacial neuropathic pain associated with infraorbital nerve injury. Int J Mol Sci. 21: 6384. Ikutame D, Urata K, Oto T, Fujiwara S, Iinuma I, Shibuta I, Hayashi Y, Hitomi S, Iwata K, Shinoda M. (2020) Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity. Int J Mol Sci. 21: 7871. Kanno K, Shimizu K , Shinoda M, Hayashi M, Takeichi O, Iwata K. (2020) Role of macrophage-mediated Toll-like receptor 4–interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation. J Neuroinflammation. 17: 312. Ando M, Hayashi H, Hitomi S, Shibuta I, Furukawa A, Oto T, Inada T, Matsui T, Fukaya C, Noma N, Okubo M, Yonehara Y, Kaneko T, Iwata K, Shinoda M. (2020) Oxytocin-dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons attenuates Orofacial Neuropathic Pain following Infraorbital Nerve Injury in Rats. Int J Mol Sci. 21(23):9173. Koga Y, Tsuchimoto D , Hayashi Y, Abolhassani N, Yoneshima Y, Sakumi K, Nakanishi H, Toyokuni S, Nakabeppu Y. (2020) Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy. JCI Insight. 5(22):e140229. Morii A, Miyamura Y, Sago-Ito M, Mizuhara M, Shikayama T, Naniwa M, Hitomi S, Ujihara I., Kuroishi K, Gunjigake K, Shiga M, Morimoto Y, Kawamoto T, Ono K (2020) Orthodontic force-induced oxidative stress in the periodontal tissue and dental pulp elicits nociception via activation/sensitization of TRPA1 on nociceptive fibers. Free Radic Biol Med. 147:175-186. Shikayama T, Fujita-Yoshigaki J, Sago-Ito M, Nakamura-Kiyama M, Naniwa M, Hitomi S, Ujihara I, Kataoka S, Yada N, Ariyoshi W, Usui M, Nakashima K, Ono K . (2020) Hematogenous apoptotic mechanism in salivary glands in chronic periodontitis. Arch Oral Biol. 117:104775. Hitomi S , Kokabu S, Matsumoto K, Shoji Y, Ujihara I, Ono K. (2020) Expression of ascorbate peroxidase derived from Cyanidioschyzon merolae in mammalian cells. In Vivo. 34(5):2437-2441. Miyawaki A, Rojasawasthien T, Hitomi S, Aoki Y, Urata M, Inoue A, Matsubara T, Morikawa K, Habu M, Tominaga K, Kokabu S . (2020) Oral administration of geranylgeraniol rescues denervation-induced muscle atrophy via suppression of atrogin-1. In Vivo. 34(5):2345-2351. Mizuhara M, Kometani-Gunjigake K , Nakao-Kuroishi K, Toyono T, Hitomi S, Morii A, Shiga M, Seta Y, Ono K, Kawamoto T. (2020) Vesicular nucleotide transporter mediates adenosine triphosphate release in compressed human periodontal ligament fibroblast cells and participates in tooth movement-induced nociception in rats. Arch Oral Biol. 110:104607.
2019
総説
今村佳樹 ，岡田明子，野間 昇，篠崎貴弘，篠田雅路，岩田幸一 (2019)「臨床からみた難治性疼痛の機序」バーニングマウス症候群 ペインクリニック 40(3):337-349.Imamura Y, Shinozaki T, Okada-Ogawa A, Noma N, Shinoda M, Iwata K, Wada A, Abe O, Wang K, Svensson P. (2019) An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives. J Oral Rehabil. 46(6):574-587.Iwata K , Shinoda M. (2019) Role of neuron and non-neuronal cell communication in persistent orofacial pain. J Dent Anesth Pain Med. 19(2):77-82.Shinoda M, Kubo A, Hayashi Y, Iwata K . (2019) Peripheral and Central Mechanisms of Persistent Orofacial Pain. Front Neurosci. 13:1227. Hitomi S , Ujihara I, Ono K. (2019) Pain mechanism of oral ulcerative mucositis and the therapeutic traditional herbal medicine hangeshashinto. J Oral Biosci. 61(1):12-15.
原著
Shinoda M, Fukuoka T , Takeda M, Iwata K, Noguchi K. (2019) Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model. Mol Pain. 15:1744806919841196. Yoshida S, Hagiwara Y , Tsuchiya M, Shinoda M, Koide M, Hatakeyama H, Chaweewannakorn C, Yano T, Sogi Y, Itaya N, Sekiguchi T, Yabe Y, Sasaki K, Kanzaki M, Kanzaki M, Itoi E. (2019) Involvement of inflammasome activation via elevation of uric acid level in nociception in a mouse model of muscle pain. Mol Pain. 15:1744806919858797. Goto T, Nakagami G, Minematsu T, Tomida S, Shinoda M, Iwata K, Sanada H . (2019) Topically injected adrenocorticotropic hormone induces mechanical hypersensitivity on a full-thickness cutaneous wound model in rats. Exp Dermatol. 28(9):1010-1016. Goto T, Nakagami G, Minematsu T, Shinoda M, Sanada H. (2019) Measurement of mechanical withdrawal threshold on full-thickness cutaneous wounds in rats using the von Frey test. J Wound Care. 28(11):762-772. Sugawara S, Shinoda M, Hayashi Y, Saito H, Asano S, Kubo A, Shibuta I, Furukawa A, Toyofuku A, Iwata K. (2019) Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain. Int J Mol Sci. 20(24): E6360. Zhang J, Harada Y, Hayashi Y. (2019) A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice. Sci Rep. 9(1):12003. Harada Y, Zhang J, Imari K, Yamasaki R, Ni J, Wu Z, Yamamoto K, Kira JI, Nakanishi H, Hayashi Y. (2019) Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis. Pain. 160(9):2050-2062. Imari K, Harada Y, Zhang J, Mori Y, Hayashi Y. (2019) KCNMB3 in spinal microglia contributes to the generation and maintenance of neuropathic pain in mice. Int J Mol Med. 44(4):1585-1593. Matsuda T , Irie T, Katsurabayashi S, Hayashi Y, Nagai T, Hamazaki N, Adefuin AMD, Miura F, Ito T, Kimura H, Shirahige K, Takeda T, Iwasaki K, Imamura T, Nakashima H. (2019) Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion. Neuron. 101(3):472-485.e7.Ni J, Wu Z, Stoka V, Meng J, Hayashi Y, Peters C, Qing H, Turk V, Nakanishi H. (2019) Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice. Aging cell. 18(1): e12856. Hitomi S, Ujihara I, Sago-Ito M, Nodai T, Shikayama T, Inenaga K, Ono K. (2019) Hyposalivation due to chemotherapy exacerbates oral ulcerative mucositis and delays its healing. Arch Oral Biol. 105:20-26. Miyano K, Eto M, Hitomi S, Matsumoto T, Hasegawa S, Hirano A, Nagabuchi K, Asai N, Uzu M, Nonaka M, Omiya Y, Kaneko A, Ono K, Fujii H, Higami Y, Kono T, Uezono Y. (2019) The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis. Sci Rep.10(1):625. Okada S, Katagiri A , Saito H, Lee J, Ohara K, Iinuma T, Bereiter DA, Iwata K. (2019) Differential activation of ascending noxious pathways associated with trigeminal nerve injury. Pain.160(6):1342-1360. Okada S, Katagiri A , Saito H, Lee J, Ohara K, Iinuma T, Iwata K. (2019) Functional involvement of nucleus tractus solitarii neurons projecting to the parabrachial nucleus in trigeminal neuropathic pain. J Oral Sci. 61(2):370-378. Okada S, Saito H, Matsuura Y, Mikuzuki L, Sugawara S, Onose H, Asaka J, Ohara K, Lee J, Iinuma T, Katagiri A , Iwata K. (2019) Upregulation of calcitonin gene-related peptide, neuronal nitric oxide synthase, and phosphorylated extracellular signal-regulated kinase 1/2 in the trigeminal ganglion after bright light stimulation of the eye in rats. J Oral Sci. 61(1):146-155.
2018
総説
篠田雅路 （2018）顎顔面口腔領域における疼痛伝達機構の可塑的変化．日本口腔顔面痛学会誌11(1):9-14.
原著
Ito R, Shinoda M, Honda K, Urata K, Lee J, Maruno M, Soma K, Okada S, Gionhaku N, Iwata K. (2018) Tumor necrosis factor alpha signaling in trigeminal ganglion contributes to mechanical hypersensitivity in masseter muscle during temporomandibular joint inflammation. J Oral Facial Pain Headache. 32(1):75-83. Watanabe M, Shinoda M, Batbold D, Sugano N, Sato S, Iwata K. (2018) Peripheral glial cell line-derived neurotrophic factor facilitates the functional recovery of mechanical nociception following inferior alveolar nerve transection in rats. J Oral Facial Pain Headache. 32(3):229-237. Yoshida S , Hagiwara Y, Tsuchiya M, Shinoda M, Koide M, Hatakeyama H, Chaweewannakorn C, Yano T, Sogi Y, Itaya N, Sekiguchi T, Yabe Y, Sasaki K, Kanzaki M, Itoi E. (2018) Involvement of neutrophils and interleukin-18 in nociception in a mouse model of muscle pain. Mol Pain. 14:1744806918757286.Furukawa A, Shinoda M , Kubo A, Honda K, Akasaka R, Yonehara Y, Iwata K. (2018) Endothelin signaling contributes to modulation of nociception at early stage tongue cancer in rats. Anesthesiology. 128(6):1207-1219. Watase T, Shimizu K , Ohara K, Komiya H, Hatori K, Noma N, Honda K, Tsuboi Y, Katagiri A, Shinoda M, Ogiso B, Iwata K. (2018) Role of medullary astroglial glutamine synthesis in tooth pulp hypersensitivity associated with frequent masseter muscle contraction. Mol Pain. 14:1744806918763270. Urata K, Shinoda M, Ikutame D, Iinuma T, Iwata K. (2018) Involvement of transient receptor potential vanilloid 2 in intra-oral incisional pain. Oral Diseases. 24(6):1093-1100. Lee J, Yamate C, Taira M, Shinoda M, Urata K, Maruno M, Ito R, Saito H, Gionhaku N, Iinuma T, Iwata K. (2018) Prefrontal cortex activity during swallowing in dysphagia patients. J Oral Sci. 60(3):329-335. Komiya H, Shimizu K, Ishii K, Kudo H, Okamura T, Kanno K, Shinoda M, Ogiso B, Iwata K. (2018) Connexin 43 expression in satellite glial cells contributes to ectopic tooth-pulp pain. J Oral Sci. 60(4):493-499. Tsuchiya M , Aida J, Watanabe T, Shinoda M, Sugawara Y, Tomata Y, Yabe Y, Sekiguchi T, Watanabe M, Osaka K, Sasaki K, Hagiwara Y, Tsuji I. (2018) High Prevalence of Toothache among Great East Japan Earthquake Survivors Living in Temporary Housing: A Panel Study. Community Dent Oral Epidemiol. 47(2):119-126.Morita I, Oyama H, Kanda Y, Yasuo M, Ito A, Toyota M, Hayashi Y, Yokoyama T, Kobayashi N. (2018) Enantioselective Monoclonal Antibodies for Detecting Ketamine to Crack Down on Illicit Use. Biol Pharm Bull. 41(1):123-131. Nishimura S, Tanaka T, Oda M, Habu M, Kodama M, Yoshiga D, Osawa K, Kokuryo S, Miyamoto I, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Joujima T, Miyamura Y, Hitomi S, Yamamoto N, Uehara M, Sasaguri M, Ono K, Yoshioka I, Tominaga K, Morimoto Y. (2018) Functional evaluation of swallowing in patients with tongue cancer before and after surgery using high-speed continuous magnetic resonance imaging based on T2-weighted sequences. Oral Surg Oral Med Oral Pathol Oral Radiol. 125(1):88-98. Nodai T，Hitomi S，Ono K ，Masaki C，Harano N，Morii A，Sago-Ito M，Ujihara I，Hibino T，Terawaki K，Omiya Y，Hosokawa R，Inenaga K. (2018) Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model. J Dent Res. 97(8):901-908.
2017
著書
Iwata K, Takeda M, Oh SB, Shinoda M. [Camile S. Farah, Ramesh Balasubramaniam and Michael John McCullough Editor] (2017) Neurophysiology of Orofacial Pain [Contemporary Oral Medicine] Springer International Publishing, DOI: 10.1007/978-3-319-28100-1_8-3.
総説
岩田幸一 ，久保亜抄子，片桐綾乃，篠田雅路 (2017) 網様体，三叉神経脊髄路核および孤束核への感覚入力 CLINICAL NEUROSCIENCE 35(6):665-668.Iwata K , Katagiri A, Shinoda M. (2017) Neuron-glia interaction is a key mechanism underlying persistent orofacial pain. J Oral Sci. 59(2):173-175.Shinoda M , Noma N. (2017) Pathophysiology and treatment of orofacial pain. Clin Calcium. 27(10):1375-1382.Inenaga K , Ono K, Hitomi S, Kuroki A, Ujihara I. (2017) Thirst sensation and oral dryness following alcohol intake. Jpn Dent Sci Rev. 53(3):78-85.
原著
Kubo A , Shinoda M, Katagiri A, Takeda M, Suzuki T, Asaka J, Yeomans D, Iwata K. (2017) Oxytocin alleviates orofacial mechanical hypersensitivity associated with infraorbital nerve injury via vasopressin 1A receptors of the rat trigeminal ganglia. Pain. 158(4):649-659. Hossain MZ , Shinoda M, Unno S, Ando H, Masuda Y, Iwata K, Kitagawa J. (2017) Involvement of microglia and astroglia in modulation of the orofacial motor functions in rats with neuropathic pain. J. Oral Biosci. 59(1):17-22.Nagashima H, Shinoda M, Honda K, Kamio N, Watanabe M, Suzuki T, Sugano N, Sato S, Iwata K. (2017) CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis -induced periodontitis in mice. Mol Pain. 13:1744806916689269. Nagashima H, Shinoda M, Honda K, Kamio N, Hasuike A, Sugano N, Arai Y, Sato S, Iwata K. (2017) CXCR4 signaling contributes to alveolar bone resorption in Porphyromonas gingivalis -induced periodontitis in mice. J Oral Sci. 59(4):571-577. Hitomi S, Okada-Ogawa A , Sato Y, Shibuta-Suzuki I, Shinoda M, Imamura Y, Ono K, Iwata K. (2017) Enhancement of ERK phosphorylation and photic responses in Vc/C1 neurons of a migraine model. Neurosci Lett. 647:14-19. Maruno M, Shinoda M, Honda K, Ito R, Urata K, Watanabe M, Okada S, Lee J, Gionhaku N, Iwata K. (2017) p38 phosphorylation in trigeminal ganglion neurons contributes tongue heat hypersensitivity in mice. J Oral Facial Pain Headache. 31(4):372-380. Honda K , Shinoda M, Kondo M, Shimizu K, Yonemoto H, Otsuki K, Akasaka R, Furukawa A, Iwata K. (2017) Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity. Pain. 158(9):1754-1764.Komiya H, Shimizu K , Noma N, Tsuboi Y, Honda K, Kanno K, Ohara K, Shinoda M, Ogiso B, Iwata K. (2017) Role of Neuron-Glial Interaction Mediated by IL-1β in Ectopic Tooth Pain. J Dent Res. 97(4):467-475. Batbold D, Shinoda M , Honda K, Furukawa A, Koizumi M, Akasaka R, Yamaguchi S, Iwata K. (2017) Macrophages in trigeminal ganglion contribute to ectopic mechanical hypersensitivity following inferior alveolar nerve injury in rats. J Neuroinflammation. 14:249. Saito H, Katagiri A , Okada S, Mikuzuki L, Kubo A, Suzuki T, Ohara K, Lee J, Gionhaku N, Iinuma T, Bereiter DA, Iwata K. (2017). Ascending projections of nociceptive neurons from trigeminal subnucleus caudalis: A population approach. Exp Neurol. 293:124-136. Sugawara S, Okada S, Katagiri A , Saito H, Suzuki T, Komiya H, Kanno K, Ohara K, Iinuma T, Toyofuku A, Iwata K. (2017) Interaction between calcitonin gene-related peptide-immunoreactive neurons and satellite cells via P2Y12 R in the trigeminal ganglion is involved in neuropathic tongue pain in rats. Eur J Oral Sci. 125(6):444-452. Mikuzuki L, Saito H, Katagiri A , Okada S, Sugawara S, Kubo A, Ohara K, Lee J, Toyofuku A, Iwata K. (2017) Phenotypic change in trigeminal ganglion neurons associated with satellite cell activation via extracellular signal-regulated kinase phosphorylation is involved in lingual neuropathic pain. Eur J Neurosci. 46(6):2190-2202. Liu Y, Wu Z, Nakanishi Y, Ni J, Hayashi Y, Takayama F, Zhou Y, Kadowaki T, Nakanishi H. (2017) Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice. Sci Rep. 7(1):11759. Takayama F, Zhang X, Hayashi Y, Wu Z, Nakanishi H. (2017) Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice. Biochem Biophys Res Commun. 490(2):447-452. Harada Y, Takayama F, Tanabe K, Ni J, Hayashi Y, Yamamoto K, Wu Z, Nakanishi H. (2017) Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin. Cell Mol Neurobiol. 37(3):437-443. Hitomi S, Ono K , Terawaki K, Matsumoto C, Mizuno K, Yamaguchi K, Imai R, Omiya Y, Hattori T, Kase Y, Inenaga K. (2017) [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na+ channels. Pharmacol Res. 117:288-302. Hitomi S, Kross K, Kurose M, Porreca F, Meng ID. (2017) Activation of dura-sensitive trigeminal neurons and increased c-Fos protein induced by morphine withdrawal in the rostral ventromedial medulla. Cephalalgia. 37(5):407-417. Ito M, Ono K , Hitomi S, Nodai T, Sago T, Yamaguchi K, Harano N, Gunnjigake K, Hosokawa R, Kawamoto T, Inenaga K. (2017) Prostanoid-dependent spontaneous pain and PAR2-dependent mechanical allodynia following oral mucosal trauma: involvement of TRPV1, TRPA1 and TRPV4. Mol Pain. 13:1744806917704138. Kokabu S , Nakatomi C, Matsubara T, Ono Y, Addison WN, Lowery JW, Urata M, Hudnall AM, Hitomi S, Nakatomi M, Sato T, Osawa K, Yoda T, Rosen V, Jimi E. (2017) The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor. J Biol Chem. 292(31):12885-12894.Ono K, Viet CT, Ye Y, Dang D, Hitomi S, Toyono T, Inenaga K, Dolan JC, Schmidt BL. (2017) Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signaling. Sci Rep. 7(1):9181.
