研究業績

2024

Yamamoto K, Chen QY, Zhou Z, Kobayashi M, Zhuo M (2024) Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex. Phil Trans Royal Soc B, in press.

Yamamoto K, Kosukegawa S, Kobayashi M (2024) P2X receptor- and postsynaptic NMDA receptor-mediated long-lasting facilitation of inhibitory synapses in the rat insular cortex. Neuropharmacology, 245, 109817.

Kobayashi S, Kajiwara M, Cui Y, Sako T, Sasabe T, Hayashinaka E, Wada Y, Kobayashi M (2024) Activation of multiple neuromodulatory systems in alert rats acquiring conditioned taste aversion revealed by positron emission tomography. Brain Res, 1822, 148617.

2023

Nakaya Y, Kosukegawa S, Kobayashi S, Hirose K, Kitano K, Mayahara K, Takei H, Motoyoshi M, Kobayashi M (2023) Insulin potentiates inhibitory synaptic currents between fast-spiking and pyramidal neurons in the rat insular cortex. Neuropharmacology, 238, 109649.

Nakaya Y, Yamamoto K, Kobayashi M (2023) Descending projections from the insular cortex to the trigeminal spinal subnucleus caudalis facilitate excitatory outputs to the parabrachial nucleus in rats. PAIN, 164, e157-173.

Nakaya Y, Iwata K, Kobayashi M (2023) Insular cortical descending projections facilitate neuronal responses to noxious but not innoxious stimulation in rat trigeminal spinal subnucleus caudalis. Brain Res, 1804, 148248

Kosukegawa S, Nakaya Y, Kobayashi S, Kitano K, Matsumura S, Ogisawa S, Zama M, Motoyoshi M, Kobayashi M (2023) Insulin facilitates synaptic transmission via gap junctions between fast-spiking interneurons in the rat insular cortex. J Oral Sci, 65, 77-80.

2022

Sugawara S, Nakaya Y, Matsumura S, Hirose K, Saito Y, Kaneko R, Kobayashi M (2022) Neural subtype-dependent cholinergic modulation of neural activities by activation of M2 receptors and GIRK in rat periaqueductal gray neurons. Neuroscience, 506, 1-13.

Kobayashi S, O’Hashi K, Kobayashi M (2022) Repetitive nociceptive stimulation increases spontaneous neural activation similar to nociception-induced activity in mouse insular cortex．Sci Rep, 12, 15190.

Kirihara Y, Zama M, Fujita S, Ogisawa S, Nishikubo S, Tonogi M, Kobayashi M (2022) Asymmetrical organization of oral structures in the primary and secondary somatosensory cortices in rats: An optical imaging study. Synapse, 76, e22222.

Kobayashi S, O'Hashi K, Kaneko K, Kobayashi S, Ogisawa S, Tonogi M, Fujita S, Kobayashi M (2022) A new phenotype identification method with the fluorescent expression in cross-sectioned tails in Thy1-GCaMP6s transgenic mice. J Oral Sci, 64, 156-160.

2021

Hirose K, Nakaya Y, Kitano K, Saito Y, Kaneko R, Yanagawa Y, Yamamoto K, Shirakawa T, Kobayashi M (2021) Differential regulation of medium spiny and cholinergic neurons in the nucleus accumbens core by the insular and medial prefrontal cortices in the rat. Pflügers Archiv, 473, 1911-1924.

Yamamoto K, Nakaya Y, Sugawara S, Kobayashi M (2021) Synchronous inhibitory synaptic inputs to layer II/III pyramidal neurons in the murine barrel cortex. Brain Res, 1773, 147686.

Matsumura S, Yamamoto K, Nakaya Y, O'Hashi K, Kaneko K, Takei H, Tsuda H, Shirakawa T, Kobayashi M (2021) Presynaptic NK1 receptor activation by substance P suppresses EPSCs via nitric oxide synthesis in the rat insular cortex. Neuroscience, 455, 151-164.

Koyanagi Y, Oi, Y, Kobayashi M (2021) Fast-spiking interneurons contribute to propofol-induced facilitation of firing synchrony in pyramidal neurons of the rat insular cortex. Anesthesiology, 134, 219-233.

Horinuki E, O’Hashi K, Kobayashi M (2021) In vivo Ca2+ imaging of insular cortex during experimental tooth movement. J Dent Res, 100, 276-282.

大橋 一徳, 中谷 有香, 菅原 詩織, 山本 清文, 小林 真之（2021）歯学部での薬理学教育における対面講義とオンライン講義による学修成績の比較検討. 歯科薬物療法，40, 73-82.

2020

Omagari D, Hayatsu M, Yamamoto K, Kobayashi M, Tsukano N, Nameta M, Mikami Y (2020) Gap junction with MLO-A5 osteoblast-like cell line induces ALP and BSP transcription of 3T3-L1 pre-adipocyte like cell line via Hspb1 while retaining adipogenic differentiation ability. Bone, 141, 115596.

Kajiwara M, Kato R, Oi Y, Kobayashi M (2020) Propofol decreases spike firing frequency with an increase in spike synchronization in the cerebral cortex. J Pharm Sci, 142:83-92.

Kobayashi M, Nakaya Y (2020) Anatomical aspects of corticotrigeminal projections to the medullary dorsal horn. J Oral Sci. 62, 144-146.

Mizoguchi N, Muramoto K, Kobayashi M (2020) Olfactory signals from the main olfactory bulb converge with taste information from the chorda tympani nerve in the agranular insular cortex of rats. Pflügers Arch, 472, 721-732.

Noma D, Fujita S, Zama M, Mayahara K, Motoyoshi M, Kobayashi M (2020) Application of oxytocin with low-level laser irradiation suppresses the facilitation of cortical excitability by partial ligation of the infraorbital nerve in rats: An optical imaging study. Brain Res, 1728, 146588.

2019

Fujita S, Yamamoto K, Kobayashi M (2019) Trigeminal nerve transection-induced neuroplastic changes in the somatosensory and insular cortices in a rat ectopic pain model. eNeuro, 6, e0462-18.

Usui M, Kaneko K, Oi Y, Kobayashi M (2019) Orexin facilitates GABAergic IPSCs via postsynaptic OX1 receptors coupling to the intracellular PKC signalling cascade in the rat cerebral cortex. Neuropharmacology, 149, 97-112.

Murayama S, Yamamoto K, Fujita S, Takei H, Inui T, Ogiso B, Kobayashi M (2019) Extracellular glucose-dependent IPSC enhancement by leptin in fast-spiking to pyramidal neuron connections via JAK2-PI3K pathway in the rat insular cortex. Neuropharmacology, 149, 133-148.

Zama M, Fujita S, Nakaya Y, Tonogi M, Kobayashi M (2019) Preceding administration of minocycline suppresses plastic changes in cortical excitatory propagation in the model rat with partial infraorbital nerve ligation. Front Neurol, 10, 1150.

2018

Yamamoto K and Kobayashi M (2018) Opposite roles in short-term plasticity for N-type and P/Q-type voltage-dependent calcium channels in GABAergic neuronal connections in the rat cerebral cortex. J Neurosci, 38, 9814-9828.

Zama M, Hara Y, Fujita S, Kaneko T, Kobayashi M (2018) Somatotopic organization and temporal characteristics of cerebrocortical excitation in response to nasal mucosa stimulation with and without an odor in the rat: an optical imaging study. Neuroscience, 377, 77-86.

Kato R, Yamanaka M, Kobayashi M (2018) Application of unfolding transformation in the random matrix theory to analyze in vivo neuronal spike firing during awake and anesthetized conditions. J Pharmacol Sci, 136, 172-176.

Kaneko M, Fujita S, Shimizu N, Motoyoshi M, Kobayashi M (2018) Experimental tooth movement temporally changes neural excitation and topographical map in rat somatosensory cortex. Brain Res, 1698, 62-69.

Ohtani S, Fujita S, Hasegawa K, Tsuda H, Tonogi M, Kobayashi M (2018) Relationship between the fluorescence intensity of rhodamine-labeled orexin A and the calcium responses in cortical neurons: An in vivo two-photon calcium imaging study. J Pharmacol Sci, 138, 76-82.

Fujita S, Zama M, Kaneko K, Murayama S, Ohtani S, Usui M, Noma D, Tsuda H, Yamamoto K, Kobayashi M (2018) Menthol-induced facilitation of cerebrocortical excitatory propagation induced by air puff stimulation of the nasal cavity in the rat: An optical imaging study. Neurosci Lett, 696, 87-92.

2017

Fujita S, Kaneko M, Nakamura H, Kobayashi M (2017) Spatiotemporal profiles of proprioception processed by the masseter muscle spindles in rat cerebral cortex: an optical imaging study. Front Neural Circuit, 11, 4.

Aoki R, Kato R, Fujita S, Shimada J, Koshikawa N, Kobayashi M (2017) Phase-dependent activity of neurons in the rostral part of the thalamic reticular nucleus with saccharin intake in a cue-guided lever-manipulation task. Brain Res, 1658, 42-50.

Minoda A, Mizoguchi N, Kobayashi M, Suda N, Muramoto K (2017) Intracortical signal processing of periodontal ligament sensations in rat. Neuroscience, 355, 212-224.

Kaneko M, Horinuki E, Shimizu N, Kobayashi M (2017) Physiological profiles of cortical responses to mechanical stimulation of the tooth in the rat: An optical imaging study. Neuroscience, 358, 170-180.

Murayama S, Yamamoto K, Kaneko M, Ogiso B, Kobayashi M (2017) Ablation of C-fibers decreases quantal size of GABAergic synaptic transmission in the insular cortex. Neuroscience, 365, 179-191.

Takei H, Yamamoto K, Bae YC, Shirakawa T, Kobayashi M (2017) Histamine H3 heteroreceptors suppress glutamatergic and GABAergic synaptic transmission in the rat insular cortex. Front Neural Circuits, 11, 85.

Kohnomi S, Ebihara K, KObayashi M (2017) Supressive regulation of lateral inhibition between medium spiny neurons via dopamine D1 receptors in the rat nucleus accumbens shell. Neurosci Lett, 636, 58-63.

Kobayashi M, Horinuki E (2017) Neural mechanisms of nociception by orthodontic treatment. Review, J Oral Sci, 59, 167-171.

2016

Fujita S, Mizoguchi N, Aoki R, Cui Y, Koshikawa N, Kobayashi M (2016) Cytoarchitecture-Dependent Decrease in Propagation Velocity of Cortical Spreading Depression in the Rat Insular Cortex Revealed by Optical Imaging. Cereb Cortex, 26, 1580-1589.

Nakamura H, Shirakawa T, Koshikawa N, Kobayashi M (2016) Distinct excitation to pulpal stimuli between somatosensory and insular cortices. J Dent Res, 95, 180-187.

Horinuki E, Yamamoto K, Shimizu N, Koshikawa N, Kobayashi M (2016) Sequential changes in cortical excitation during orthodontic treatment. J Dent Res, 95, 897-905.

Yokota E, Koyanagi Y, Nakamura H, Horinuki E, Oi Y, Kobayashi M (2016) Opposite effects of mu and delta opioid receptor agonists on excitatory propagation induced in rat somatosensory and insular cortices by dental pulp stimulation. Neurosci Lett, 628, 53-58.

Kato R, Yamanaka M, Yokota E, Koshikawa N, Kobayashi M (2016) Spike timing rigidity is maintained in bursting neurons under pentobarbital-induced anesthetic conditions. Front Neural Circuit, in press.

Yokota E, Koyanagi Y, Yamamoto K, Oi Y, Koshikawa N, Kobayashi M (2016) Opioid subtype- and cell type-dependent regulation of inhibitory synaptic transmission in the rat insular cortex. Neuroscience, 339, 478-490.

Kaneko K, Koyanagi Y, Oi Y, Kobayashi M (2016) Propofol-induced spike firing suppression is more pronounced in pyramidal neurons than in fast-spiking neurons in the rat insular cortex. Neuroscience, 339, 548-560.

2015

Aono Y, Taguchi H, Saigusa T, Uchida T, Takada K, Takiguchi H, Shirakawa T, Shimizu N, Koshikawa N, Cools AR (2015) Simultaneous activation of α1A-, α1B- and α1D-adrenoceptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats. Behav. Pharmacol. 26(1-2), 73-80.

Horinuki E, Shinoda M, Shimizu N, Koshikawa N, Kobayashi M (2015) Orthodontic force facilitates cortical responses to periodontal stimularion. J Dent Res, 94, 1158-1166, 2015.

Ikeda H, Adachi K, Fujita S, Tomiyama K, Saigusa T, Kobayashi M, Koshikawa N, Waddington JL (2015) Investigating complex basal ganglia circuitry in the regulation of motor behaviour, with particular focus on orofacial movement. Behav Pharmacol, Behav. Pharmacol, 26(1-2), 18-32, 2015.

Mikami Y, Yamamoto K, Akiyama Y, Kobayashi M, Watanabe E, Watanabe N, Asano M, Shimizu N, Komiyama K (2015) Osteogenic Gene Transcription is Regulated via Gap Junction-Mediated Cell-Cell Communication. Stem Cells and Developmen. 24, 214-227, 2015.

Nakamura H, Kato R,Shirakawa T, Koshikawa N, Kobayashi M (2015) Spatiotemporal profiles of dental pulp nociception in rat cerebral cortex: an optical imaging study. J Comp Neurol, 523, 1162-1174, 2015.

Nishikawa Y, Akiyama Y, Yamamoto K, Kobayashi M, Watanabe E, Watanabe N, Shimizu N, Mikami Y, Komiyama K (2015) Osteocytes up-regulate the terminal differentiation of pre-osteoblasts via gap junctions. Biochem Biophys Res Commun, 456, 1-6, 2015

Okada-Ogawa A, Nakaya Y, Imamura Y, Kobayashi M, Shinoda M, Kita K, Sessle BJ, Iwata K (2015) Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection. Exp Neurol, 267, 42-52.

Verheij M.M, Saigusa T, Koshikawa N, Cools AR (2015) Accumbal α-adrenoceptors, but not β-adrenoceptors, regulate behaviour that is mediated by reserpine-sensitive storage vesicles. Behav. Pharmacol. 26, 81-90.

Yamamoto K, Takei H, Koyanagi Y, Koshikawa N, Kobayashi M (2015) Presynaptic cell-type-dependent regulation of GABAergic synaptic transmission by nitric oxide in rat insular cortex. Neuroscience, 284, 65-77, 2015.

Toyoda I, Fujita S, Thamattoor AK, Buckmaster PS (2015) Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy. J Neurosci, 35, 6600-6618.

2014

Koyanagi Y, Oi Y, Yamamoto K, Koshikawa N, Kobayashi M (2014) Fast-spiking cell to pyramidal cell connections are the most sensitive to propofol-induced facilitation of GABAergic currents in rat insular cortex. Anesthesiology, 121, 68-78.

Fujita S, Toyoda I, Thamattoor AK, Buckmaster PS (2014) Preictal Activity of Subicular, CA1, and Dentate Gyrus Principal Neurons in the Dorsal Hippocampus before Spontaneous Seizures in a Rat Model of Temporal Lobe Epilepsy. J Neurosci, 34, 16671-16687.

2013

Yamamoto K, Ebihara K, Koshikawa N, Kobayashi M (2013) Reciprocal regulation of inhibitory synaptic transmission by nicotinic and muscarinic receptors in rat nucleus accumbens shell. J Physiol, 591, 5745-5763.

Ikeda H, Saigusa T, Kamei J, Koshikawa N, Cools AR (2013) Spiraling dopaminergic circuitry from the ventral striatum to dorsal striatum is an effective feed-forward loop. Neuroscience 241, 126-134

Ikeda H, Koshikawa N, Cools AR (2013) Accumbal core: Essential link in feed-forward spiraling striato-nigro-striatal in series connected loop. Neuroscience 252:60-67

Verheij MM, Saigusa T, Koshikawa N, Cools AR (2013) Working mechanism underlying the reduction of the behavioral and accumbal dopamine response to cocaine by α1-adrenoceptor antagonists. Neuropsychopharmacology, 38, 540-1.

Kobayashi M, Cui YL, Sako T, Sasabe T, Mizoguchi N, Yamamoto K, Wada Y, Kataoka Y, Koshikawa N (2013) Functional neuroimaging of aversive taste-related areas in the alert rat revealed by positron emission tomography. J Neurosci Res, 91, 1363-70

Fujita S, Kato R, Cui Y, Terakado M, Suga K, Koshikawa N, Kobayashi M (2013) Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rats. Synapse, 67, 363-73.

Ebihara K, Yamamoto K, Ueda K, Koshikawa N, Kobayashi M (2013) Cholinergic interneurons suppress action potential initiation of medium spiny neurons in rat nucleus accumbens shell. Neuroscience, 236, 332-44.

Sato H, Toyoda H, Saito M, Kobayashi M, Althof D, Kulik Á, Kang Y (2013) GABAB receptor-mediated presynaptic inhibition reverses inter-columnar covariability of synaptic actions by intracortical axons in the rat barrel cortex. Eur J Neurosci, 37, 190-202.

Adachi K, Fujita S, Yoshida A, Sakagami H, Koshikawa N, Kobayashi M (2013) Anatomical and electrophysiological mechanisms for asymmetrical excitatory propagation in the rat insular cortex: In vivo optical imaging and whole-cell patch-clamp studies. J Comp Neurol, 521, 1598-613

Teramoto K, Tsuboi Y, Shinoda M, Hitomi S, Abe K, Kaji K, Tamagawa T, Suzuki A, Noma N, Kobayashi M, Komiyama O, Urata K, Iwata K (2013) Changes in expression of growth-associated protein-43 in trigeminal ganglion neurons and of the jaw opening reflex following inferior alveolar nerve transection in rats. Eur J Oral Sci, 121, 86-91.

Komiyama O, Nishimura H, Makiyama Y, Iida T, Obara R, Shinoda M, Kobayashi M, Noma N, Abe O, De Laat A, Kawara M (2013) Group cognitive-behavioral intervention for patients with burning mouth syndrome. J Oral Sci, 55, 17-22.

2012

Komiyama O, Obara R, Uchida T, Nishimura H, Iida T, Okubo M, Shimosaka M, Narita N, Niwa H, Shinoda M, Kobayashi M, Noma N, Abe O, Makiyama Y, Hirayama T, Kawara M (2012) Pain intensity and psychosocial characteristics of patients with burning mouth syndrome and trigeminal neuralgia. J Oral Sci, 54, 321-7.

Miyamoto M, Tsuboi Y, Honda K, Kobayashi M, Takamiya K, Huganir RL, Kondo M, Shinoda M, Sessle BJ, Katagiri A, Kita D, Suzuki I, Oi Y, Iwata K (2012) Involvement of AMPA receptor GluR2 and GluR3 trafficking in trigeminal spinal subnucleus caudalis and C1/C2 neurons in acute-facial inflammatory pain. PLoS One, 7, e44055.

Saigusa T, Aono Y, Uchida T, Takada K, Verheij MM, Koshikawa N, Cools AR (2012) The α1-, but not α2-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats. Eur J Pharmacol, 688, 35-41.

Takei H, Song L, Ebihara K, Shirakawa T, Koshikawa N, Kobayashi M (2012) Histaminergic effects on the frequency of repetitive spike firing in rat insular cortex. Neurosci Lett, 518, 55-9.

Adachi K, Kobayashi M, Kawasaki T, Yokoyama C, Waddington JL, Sakagami H, Onoe H, Koshikawa N (2012) Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease. J Neural Transm, 119, 933-41.

Fujita S, Kitayama T, Mizoguchi N, Oi Y, Koshikawa N, Kobayashi M (2012) Spatiotemporal profiles of transcallosal connections in rat insular cortex revealed by in vivo optical imaging. Neuroscience, 206, 201-11.

Kobayashi M, Takei H, Yamamoto K, Hatanaka H, Koshikawa N (2012) Kinetics of GABAB autoreceptor-mediated suppression of GABA release in rat insular cortex. J Neurophysiol, 107, 1431-42.

Saigusa T, Aono Y, Sekino R, Uchida T, Takada K, Oi Y, Koshikawa N, Cools AR (2012) In vivo neurochemical evidence that newly synthesised GABA activates GABAB, but not GABAA, receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats. Neuropharmacology, 62, 907-13.

Kohnomi S, Koshikawa N, Kobayashi M (2012) D2-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell. J Neurophysiol, 107, 692-703.

2011

Tomiyama K, Kim HA, Kinsella A, Ehrlich ME, Schütz G, Koshikawa N, Lawrence AJ, Waddington JL, Drago J (2011) Phenotypic disruption to orofacial movement topography in conditional mutants with generalized CamKIIa/Cre D1Tox versus striatal-specific DARPP-32/Cre D1Tox ablation of D1 dopamine receptor-expressing cells. Synapse, 65, 835-42.

Koshikawa N, Fujita S, Adachi K (2011) Behavioral pharmacology of orofacial movement disorders. Int Rev Neurobiol, 97, 1-38.

Tomiyama K, O'Tuathaigh CM, Waddington JL (2011) Regulation of orofacial movement: amino acid mechanisms and mutant models. Int Rev Neurobiol, 97, 61-75.

Waddington JL, O'Sullivan GJ, Tomiyama K (2011) Regulation of orofacial movement: dopamine receptor mechanisms and mutant models. Int Rev Neurobiol, 97, 39-60.

Kobayashi M (2011) Macroscopic connection of rat insular cortex: anatomical bases underlying its physiological functions. Int Rev Neurobiol, 97, 285-303.

Kobayashi M, Sasabe T, Shigihara Y, Tanaka M, Watanabe Y (2011) Gustatory imagery reveals functional connectivity from the prefrontal to insular cortices traced with magnetoencephalography. PLoS One, 6, e21736.

Mizoguchi N, Fujita S, Koshikawa N, Kobayashi M (2011) Spatiotemporal dynamics of long-term potentiation in rat insular cortex revealed by optical imaging. Neurobiol Learn Mem, 96, 468-478.

Fujita S, Koshikawa N, Kobayashi M (2011) GABAB receptors accentuate neural excitation contrast in rat insular cortex. Neuroscience, 199, 259-71.

2010

Sekino R, Saigusa T, Aono Y, Uchida T, Takada K, Oi Y, Koshikawa N, Cools AR (2010) Dopamine D(1)-like receptors play only a minor role in the increase of striatal dopamine induced by striatally applied SKF38393. Eur J Pharmacol. 648, 80-6.

Takei H, Fujita S, Shirakawa T, Koshikawa N, Kobayashi M (2010) Insulin facilitates repetitive spike firing in rat insular cortex via phosphoinositide 3-kinase but not mitogen activated protein kinase cascade. Neuroscience. 170, 1199-208.

Yamamoto K, Koyanagi Y, Koshikawa N, Kobayashi M (2010) Postsynaptic cell type-dependent cholinergic regulation of GABAergic synaptic transmission in rat insular cortex. J Neurophysiol, 1041933-45.

Koyanagi Y, Yamamoto K, Oi Y, Koshikawa N, Kobayashi M (2010) Presynaptic interneuron subtype- and age-dependent modulation of GABAergic synaptic transmission by beta-adrenoceptors in rat insular cortex. J Neurophysiol, 103, 2876-88.

Chen S, Fujita S, Koshikawa N, Kobayashi M (2010) Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. Neuroscience, 166, 341-53. COVER ILLUSTRATION

Fujita S, Adachi K, Koshikawa N, Kobayashi M (2010) Spatiotemporal dynamics of excitation in rat insular cortex: intrinsic corticocortical circuit regulates caudal-rostro excitatory propagation from the insular to frontal cortex. Neuroscience, 165, 278-92.

Fujita S, Kiguchi M, Kobayashi M, Kinsella A, Koshikawa N, Waddington JL (2010) Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959. Eur J Pharmacol, 632, 39-44.

Fujita S, Kiguchi M, Kobayashi M, Koshikawa N, Waddington JL (2010) Involvement of NMDA receptors in the ventrolateral striatum of rats in apomorphine-induced jaw movements. Brain Res, 1322, 30-7.

Ikeda H, Kotani A, Koshikawa N, Cools AR (2010) Differential role of GABAA and GABAB receptors in two distinct output stations of the rat striatum: studies on the substantia nigra pars reticulata and the globus pallidus. Neuroscience, 167, 31-9.

Kobayashi M, Fujita S, Takei H, Song L, Chen S, Suzuki I, Yoshida A, Iwata K, Koshikawa N (2010) Functional mapping of gustatory neurons in the insular cortex revealed by pERK-immunohistochemistry and in vivo optical imaging. Synapse, 64, 323-34.

Ikeda H, Miyatake M, Koshikawa N, Ochiai K, Yamada K, Kiss A, Donlin MJ, Panneton WM, Churchill JD, Green M, Siddiqui AM, Leinweber AL, Crews NR, Ezerskiy LA, Rendell VR, Belcheva MM, Coscia CJ (2010) Morphine modulation of thrombspondin levels in astrocytes and its implications for neurite outgrowth and synapse formation. J Biol Chem, 285, 38415-27.

Adachi K, Shimizu K, Hu JW, Suzuki I, Sakagami H, Koshikawa N, Sessle BJ, Shinoda M, Miyamoto M, Honda K, Iwata K (2010) Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity. Mol Pain, 6, 59.

2009

Tomiyama K, O'Tuathaigh CM, O'Sullivan GJ, Kinsella A, Lai D, Harvey RP, Tighe O, Croke DT, Koshikawa N, Waddington JL (2009) Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice. Prog Neuropsychopharmacol Biol Psychiatry, 33, 330-333.

Saigusa T, Aono Y, Sekino R, Uchida T, Takada K, Oi Y, Koshikawa N, Cools AR (2009) Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of SKF38393. Eur J Pharmacol, 624, 10-15.

Kobayashi M, Kojima M, Koyanagi Y, Adachi K, Imamura K, Koshikawa N (2009) Presynaptic and postsynaptic modulation of glutamatergic synaptic transmission by activation of alpha(1)- and beta-adrenoceptors in layer V pyramidal neurons of rat cerebral cortex. Synapse, 63, 269-281.

Ikeda H, Kotani A, Koshikawa N, Cools AR (2009) Somatostatin receptors in the nucleus accumbens modulate dopamine-dependent but not acetylcholine-dependent turning behaviour of rats. Neuroscience, 159, 974-981.

Ikeda H, Kotani A, Lee J, Koshikawa N, Cools AR (2009) GABAA receptors in the mediodorsal thalamus play a crucial role in rat shell-specific acetylcholine-mediated, but not dopamine-mediated, turning behaviour. Neuroscience, 159, 1200-1207.

Sugiyo S, Uehashi D, Satoh F, Abe T, Yonehara N, Kobayashi M, Takemura M (2009) Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats. Exp Brain Res, 196, 229-237.

2008

Kobayashi M, Sasabe T, Shiohama Y, Koshikawa N (2008) Activation of alpha1-adrenoceptors increases firing frequency through protein kinase C in pyramidal neurons of rat visual cortex. Neurosci Lett, 430, 175-80.

Kotani A, Ikeda H, Koshikawa N, Cools AR. Role of orexin receptors in the nucleus accumbens in dopamine-dependent turning behaviour of rats (2008) Neuropharmacology, 54, 613-619.

Kiguchi M, Fujita S, Oki H, Shimizu N, Cools AR, Koshikawa N (2008) Behavioural characterisation of rats exposed neonatally to bisphenol-A: responses to a novel environment and to methylphenidate challenge in a putative model of attention-deficit hyperactivity disorder. J Neural Transm, 115, 1079-85.

Adachi K, Murray GM, Lee JC, Sessle BJ (2008) Noxious lingual stimulation influences the excitability of the face primary motor cerebral cortex (face MI) in the rat. J Neurophysiol, 100, 1234-44.

Kobayashi M, Hamada T, Kogo M, Yanagawa Y, Obata K, Kang Y (2008) Developmental profile of GABAA-mediated synaptic transmission in pyramidal cells of the somatosensory cortex. Eur J Neurosci, 28, 849-61.

Aono Y, Saigusa T, Mizoguchi N, Iwakami T, Takada K, Gionhaku N, Oi Y, Ueda K, Koshikawa N, Cools AR (2008) Role of GABAA receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats. Eur J Pharmacol, 580, 87-94.

Saigusa T, Aono Y, Mizoguchi N, Iwakami T, Takada K, Oi Y, Ueda K, Koshikawa N, Cools AR (2008) Role of GABAB receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats. Eur J Pharmacol, 581, 276-282.

Mizoguchi N, Saigusa T, Aono Y, Sekino R, Takada K, Oi Y, Ueda K, Koshikawa N, Cools AR (2008) The reboxetine-induced increase of accumbal dopamine efflux is inhibited by l-propranolol: a microdialysis study with freely moving rats. Eur J Pharmacol, 601, 94-98.

Fujita S, Kiguchi M, Lee J, Terakado M, Suga K, Hatanaka H, Koshikawa N (2008) 5-HT1A and 5-HT1B receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats. J Oral Sci, 50, 387-395.

2007

Kiguchi M, Fujita S, Lee J, Shimizu N, Koshikawa N (2017) Behavioral responses to methylphenidate and apomorphine in rats exposed neonatally to bisphenol-A. J Oral Sci, 49, 311-318.

Ikeda H, Kotani A, Koshikawa N, Cools AR (2017) A vehicle injection into the right core of the nucleus accumbens both reverses the region-specificity and alters the type of contralateral turning elicited by unilateral stimulation of dopamine D2/D3 and D1 receptors in the left core of the nucleus accumbens. Eur J Pharmacol, 577, 64-70.

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